Beta-blockers: once or three times a day?

Once-a-day Concerta methylphenidate versus three-times-daily methylphenidate in laboratory and natural settings.

OBJECTIVE Methylphenidate (MPH), the most commonly prescribed drug for attention-deficit/hyperactivity disorder (ADHD), has a short half-life, which necessitates multiple daily doses. The need for multiple doses produces problems with medication administration during school and after-school hours, and therefore with compliance. Previous long-acting stimulants and preparations have shown effects...

Insulin degludec, an ultra-long-acting basal insulin, once a day or three times a week versus insulin glargine once a day in patients with type 2 diabetes: a 16-week, randomised, open-label, phase 2 trial.

BACKGROUND Insulin degludec is a new basal insulin that forms soluble multihexamer assemblies after subcutaneous injection, resulting in an ultra-long action profile. This study aimed to assess efficacy and safety of insulin degludec injected once a day or three times a week compared with insulin glargine once a day in insulin-naive people with type 2 diabetes, who were inadequately controlled ...

Beta-blockers: friend or foe in asthma?

BACKGROUND AND AIM Recently, β-blockers have been suggested as a potential maintenance treatment option for asthma. The aim of this review is to provide an overview of the current knowledge of the potential benefits and risks of β-blocker therapy for asthma. METHOD Systematic literature review. RESULTS No significant increase in the number of patients requiring rescue oral corticosteroid fo...

Dengue or Three-Day Fever

acute pain, and the disease is severe, with a rather slow convalescence. A secondary rash is generally present, but the desquamation following is even more noteworthy than the rash itself. During 1917 I was for some time in Cannanore, Malabar, and while there saw a good many cases of a 3 to 4 day fever. The fever was of a mild type and showed no rash. This fever occurred before the rains broke,...

Once spontaneous bacterial peritonitis develops, discontinue nonselective beta blockers permanently. A proposed practice change update.